… When your test looks for signs of TB infection using T cells, it matters how many T cells you include. Does not boost responses measured by subsequent tests. And it’s a big number: 250,000 cells per well, four wells per test. This gives an overall measurement of the host immune response against mycobacteria, which can reveal the presence of infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Other TB Tests. If you have a positive skin or blood TB test, your doctor may give you a chest X-ray. What is the T-SPOT®.TB (T-SPOT.TB) test? Prior BCG (bacille Calmette-Guérin) vaccination does not cause a false-positive IGRA test result. Requires a single patient visit to conduct the test. Accurate Results: T-SPOT TEST for detection of TB is one of the newest tests which can benefit the people with ease. Other TB tests take more patient visits and a long-time procedure and still are not very accurate. The T-SPOT ®. Results can be available within 24 hours. It is intended for use as an aid in the diagnosis of M.tuberculosis infection. The QuantiFERON TB test has been shown to be accurate in HIV-positive individuals with moderately advanced disease, but in the severely immunocompromised the test may be impaired by T-cell anergy. TB test is a unique, single-visit blood test, also known as an interferon-gamma release assay (IGRA) for TB infection. Cells Matter 1. The T-SPOT®.TB test is an in vitro diagnostic test for the detection of effector T cells that respond to stimulation by Mycobacterium tuberculosis antigens ESAT-6 and CFP 10 by capturing interferon gamma (IFN- γ) in the vicinity of T cells in human whole blood collected in sodium citrate or sodium or lithium heparin. This techniq… Because this does not rely on production of a reliable antibody response or recoverable pathogen, the technique can be used to detect latent tuberculosis. The T-SPOT.TB test, unlike other tests, uses the same number each time. 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